We have been asked many times to cover this topic. We hope this helps with some resources to understand.
"Hypermobility and mast cell activation syndrome connection?"
"One of the most striking examples of how Lyme disease co-infections can wreak havoc on the extracellular matrix and connective tissues comes from a 2018 study that looked at the effects of Bartonella infection, rheumatological symptoms and associated joint hypermobility (8). The case study publication concerned a female veterinarian who displayed the clinical symptoms of EDS (Ehlers-Danlos Syndrome).."
"You’ll learn about connective tissue, mast cell activation disorder and POTS or dysautonomia. That will all sum up EDS in a very confusing package with a not-so-pretty bow."
"In this episode, you will learn about Joint Hypermobility Syndrome and Ehlers-Danlos Syndrome."
"First up is the Hypermobile Ehlers-Danlos Syndrome, a genetic condition she’s had since birth that is part of the reason she also has Postural Orthostatic Tachycardia Syndrome, a disorder of the autonomic nervous system. There’s the Hashimoto’s thyroiditis, an autoimmune disease. Finally: Lyme disease, the primary driver of her worst symptoms, which went untreated for a period of 20 years."
POTS connection:
How do patients develop POTS?
"Increasingly we are seeing that they often inherit a genetic vulnerability such as Ehler’s Danlos syndrome/joint hypermobility syndrome and then at some point in their lives they get hit by some kind of infection, this vulnerability is unmasked and the patient starts noticing these symptoms. In essence, people are born with a genie in their lamp and then an infection comes along and the genie is unleashed and they then can't get the genie back in the lamp. The most common infection that I have come across as a trigger for dysautonomias is Glandular fever "
"Common Types of EDS There are also more common types of EDS including: Classical EDS Hypermobile EDS
Ehlers-Danlos Syndrome is a set of connective tissue disorders.
Connective tissues support your organs and hold your body together. These tissues are made of collagen and elastin. These are proteins. EDS affects your body’s ability to produce collagen. This means that with EDS, your connective tissue can be compromised."
"Many patients with Bartonellosis also exhibit symptoms of MCAS. Research proposed that mast cell activation and dysregulation plays an role in a subset of “nongenetically mediated Ehlers-Danlos Syndromes (EDS) with joint hypermobility”. Meaning it affects the connective tissue and appears similar to EDS, but is not genetic. This proposed mechanism implies that MCAS cause alterations in collagen formation."
"Around 50% of patients report that their symptoms started after a particular event like an infection or trauma and it is hypothesized that fibromyalgia can be triggered by certain types of infections (e.g., Epstein-Barr virus, hepatitis C virus, HIV, Lyme disease) as well as physical and psychological trauma "
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